Publications & research

What the researchadds up to

Across more than two decades of clinical and translational work, the publication record clusters around a small number of recurring themes. Each one is the spine of an area of clinical work, and each connects out to the relevant clinical-expertise page on this site.

Professor Paul Lee, research themes

Theme 01

Joint preservation before replacement

The core organising question across two decades of work.

A clinical and research focus on the realistic window where the joint can still be preserved, biologically supported or repaired before replacement becomes the default. Threads through the cartilage, meniscus, ligament and recovery work, and underpins the Preserve to Replace decision pathway used in clinical practice.

Theme 02

Cartilage regeneration

ChondroFiller, STACi and the single-stage cartilage repair question.

Articular cartilage repair, scaffold-augmented techniques, ChondroFiller (CFI / CFI+ / CFI++) and the single-stage Tissue-engineered Autologous Cartilage Implantation (STACi) line. The research record interrogates patient selection, evidence boundaries, mid-term outcomes and the line between focal defect repair and advanced osteoarthritis.

Theme 03

ACL repair and ligament preservation

STARR augmented repair and the case against default reconstruction.

Single Treatment ACL Regenerative Repair (STARR), BEAR-style augmented repair and the wider preservation-first framing of acute ACL injury. The research record interrogates ligament preservation evidence, MPFL stability work and the return-to-sport pathway behind preserved-ligament surgery.

Related projects:ACL.Repair

Theme 05

Hip-preserving surgical approaches

SPAIRE and the soft-tissue discipline behind a good hip replacement.

Hip arthroplasty research with a focus on soft-tissue preservation: SPAIRE (Spare Piriformis And Internus, Repair Externus), short femoral stems, planning for leg-length equality and offset, and the materials and bearing-surface debates that frame implant choice. The book chapter and lecture record run alongside.

Theme 06

Biological augmentation and orthobiologics

Used precisely, never as a marketing category.

Polyacrylamide hydrogel (Arthrosamid), PRP, PRF, microfragmented adipose tissue (mFAT) and corticosteroid evidence. The published record spans the protocol-development work behind Professor Lee’s Arthrosamid practice, the autologous biologic options and the boundary between mechanical and biological injection effects.

Theme 07

Imaging, motion analysis and AI

Movement medicine, made measurable.

Markerless motion capture, MAI Motion biomechanical biomarkers, AI-driven MRI interpretation (onMRI) and explainable AI in healthcare. The published work supports the device-development work behind MAI Motion and onMRI and frames the case for AI as a clinical-decision support tool rather than a black box.

Theme 08

Recovery and rehabilitation optimisation

Recovery is part of the operation, not after it.

Peri-operative nutrition, blood-flow restriction training, unloading knee braces, the recovery-as-system framing that runs through the RegenPhD work. The published record connects the clinical pathway with the recovery layer that determines whether the clinical input becomes a result.

Theme 09

Consent and clinical pathway design

Digital consent as a research problem, not a paperwork problem.

Digital consent, cost-consequence analysis and informed-consent research. Connected to the Consent Plus work that won The Health Foundation Innovation Award. The pathway-design strand interrogates how the consent conversation, the decision pathway and the recovery plan fit together.

Theme 10

Knee replacement decision-making

Partial vs total, alignment philosophy, patellofemoral discipline.

Knee arthroplasty research with the same preservation discipline as the cartilage and meniscus work: partial vs total decisions, alignment philosophy, patellofemoral compartment management and the soft-tissue balancing that drives functional outcome. Includes TWIS-TKR development.

Theme 11

Regenerative orthopaedics, end-to-end

The synthesis of the themes above into a clinical discipline.

Microfragmented adipose tissue, Actovegin and biological augmentation across the musculoskeletal system. The synthesis question across all of the work above: how the regenerative-orthopaedics field actually advances, what survives translation from the bench and what does not. Underpins the Springer Nature Editor-in-Chief reference textbook.

Continue

The wider record

Privacy & Cookies Policy